Friday, June 24, 2005

Fertility Procedures - Part 2 (AIH, IUI, SO-IUI,clomid)

Before one consider IVF & ICSI, there is AIH, IUI, SO-IUI and clomid to consider.

Clomid is basically hormone medicine to trick the brain into ovulating. this is the cheapest form of fertitlity treatment and the only non invasive one, and also the first course in treating fertility issues.

Taken from kkh website.

How Is Clomid Given?
Your doctor will usually start you off on the smallest dosage which is 50 mg (1 tablet) daily. This is taken for 5 days either from the 2nd or the 5th day of your menstrual cycle.
The doctor will check for the effectiveness of this dosage by taking a blood test (serum progesterone) on the 21st to 23rd day of your menstrual cycle. The dosage can then be increased if necessary.

You are advised to have sexual intercourse between the 6th and 21st day of your menstrual cycle.
After 4-6 cycles of clomid, one has to consider other alternatives, which involves artificial insemination. There are various types to consider depending on the situation one is in.

AIH - Artificial insemination by Husband.

IUI - Inter utarine insemination (not neccesarily using husbands sperm)
and SO-IUI - which involves taking hormones to ensure super ovulation where more eggs are produced.

AiH and IUI basically work the same way as SO-IUI without the super ovulation bit.

What Is Superovulation & Intrauterine Insemination (SO-IUI)?
Superovulation is a procedure where two to three ovarian follicles (eggs) are stimulated and brought to maturation and ovulation.
It is usually combined with intrauterine insemination in which the prepared sperms are placed directly into the uterus. This procedure will enhance conception for the couple.

Who Is Suitable For SO-IUI?
Any couple who has unexplained infertility, mild male factor infertility, cervical factor infertility and mild endometriosis can undergo this procedure. The patient must have normal fallopian tubes and her husband should have sufficient good quality sperms.
If the husband requires chemotherapy or radiotherapy for cancer treatment, he may have his sperms cryopreserved (frozen) for future use by this procedure.

How Is The Procedure Done?
The procedure is done on an outpatient basis.
Fertility drugs are given for 10 days or more to produce between two to three mature follicles. These drugs may be either injections (gonadotrophins) alone or a combination of tablets (Clomiphene) and injections. Ultrasound scans are done at intervals to determine the number and size of the follicles before another injection (HCG) is given for final maturation and subsequent ovulation of these follicles.

On the day of the insemination, the couple has to bring the husband's semen sample to the hospital. The semen is prepared and the motile fraction is then placed into the uterus using a fine catheter through the cervix.

The patient is then started on medications to help improve the chances of implantation and thus pregnancy. A blood test (serum progesterone) is taken seven days after the insemination to monitor the effectiveness of these medications. The patient should return to KKIVF 17 days after the insemination for a pregnancy test.

Useful Information

Success rates (KKIVF rates)
Natural conception in a fertile couple aged about 35 years old occurs about 15% per month. When infertility factors are present, this is much reduced.

SOIUI improves the chances of conception for infertile couples and the average success rate is about 12-15% per cycle or 26% per patient after 3 cycles.

The overall success rate varies with the cause of infertility and the age of the female partner. For some conditions, the pregnancy rate can be as high as 36% per patient.

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